Patents / References
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Patents

No. Title App./Reg. No. App./Reg. Country
1. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 10-1613618 KR
2. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom PCT/KR2015/007118 PCT
3. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 15/324,277 US
4. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 2017-501265 JP
5. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 15819565.1 EU

Neoderm®-ED

No. References Journal File
1. IL-32γ suppressed atopic dermatitis through inhibition of miR-205 expression via inactivation of nuclear factor-kappa B J allergy clin immunol. 2020
2. Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis Phytomedicine. 2020
3. Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model Bioorganic & Medical Chemistry Letters. 2020
4. rhEGF Treatment Improves EGFR Inhibitor-Induced Skin Barrier and Immune Defects Cancers. 2020
5. Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells Marine drugs. 2020
6. Marine Alga Ecklonia cava Extract and Dieckol Attenuate Prostaglandin E2 Production in HaCaT Keratinocytes Exposed to Airborne Particulate Matter Antioxidants (Basel). 2019
7. Sulindac imprinted mungbean starch/PVA biomaterial films as a transdermal drug delivery patch Carbohydr Polym. 2019
8. Astragali Radix and its compound formononetin ameliorate diesel particulate matter-induced skin barrier disruption by regulation of keratinocyte proliferation and apoptosis J Ethnopharmacol. 2019
9. Effects on skin of Stichopus japonicus viscera extracts detected with saponin including Holothurin A: Down-regulation of melanin synthesis and upregulation of neocollagenesis mediated by ERK signaling pathway J Ethnopharmacol. 2018
10. PKCι is a target of 7,8,4′-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression Exp Dermatol. 2018
11. Acceleration of Apoptosis by Extracellular Basic pH in a 3D Human Skin Equivalent System Pharmacology. 2017
12. The Ginsenoside Derivative 20(S)-Protopanaxadiol Inhibits Solar Ultraviolet Light-Induced Matrix Metalloproteinase-1 Expression J Cell Biochem. 2017
13. Acceleration of Collagen Breakdown by Extracellular Basic pH in Human Dermal Fibroblasts Skin Pharmacol Physiol. 2016
14. Flt3 is a target of cumestrol in protecting against UVB-induced skin photoaging. Biochemical Pharmacology Biochem Pharmacol. 2015
15. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K PLoS One. 2015
16. Topical delivery of retinol mulsions co-stabilised by PEO-PCLPEO triblock copolymers: effect of PCL block length J Microencapsul. 2012

Neoderm®-E

No. References Journal File
1. Antimicrobial Effect of Supercritical Robinia pseudo-acacia Leaf Extracts and Its Transdermal Delivery System with Cell Penetrating Peptide International journal of advanced culture technology. 2020
2. Adiponectin enhances human keratinocyte lipid synthesis via SIRT1 and nuclear hormone receptor signaling J Invest Dermatol. 2019
3. Interleukin-17 and Interleukin-22 Induced Proinflammatory Cytokine Production in Keratinocytes via Inhibitor of Nuclear FactorκB Kinase-α Expression Ann Dermatol. 2012
4. Evaluation of the Antiviral Activity of a Green Tea Solution as a Hand-Wash Disinfectant Biosci Biotechnol Biochem. 2012
5. Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers Exp Dermatol. 2011

Neoderm®-ME

No. References Journal File
1. Anti-melanogenic effects of extracellular vesicles derived from plant leaves and stems in mouse melanoma cells and human healthy skin J extracellular vesicles. 2020
2. Exogenous pyruvate alleviates UV-induced hyperpigmentation via restraining dendrite outgrowth and Rac1 GTPase activity J dermaltological science. 2020
3. Neobavaisoflavone Inhibits Melanogenesis through the Regulation of Akt/GSK-3β and MEK/ERK Pathways in B16F10 Cells and a Reconstructed Human 3D Skin Model Molecules. 2020
4. Amino acids disrupt calcium-dependent adhesion of stratum corneum PLoS One. 2019
5. Spinosin is a flavonoid in the seed of Ziziphus jujuba that prevents skin pigmentation in a human skin model J Funct Foods. 2019
6. Effect of 3,6‐anhydro‐l‐galactose on α‐melanocyte stimulating hormone‐induced melanogenesis in human melanocytes and a skin‐equivalent model J Cell Biochem. 2018
7. Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio) propanoate suppresses melanogenesis through ERK signaling pathway mediated MITF proteasomal degradation J Dermatol Sci. 2018
8. Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin Biochem Biophys Res Commun. 2017
9. A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity J Dermatol Sci. 2018
10. Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase Oncotarget. 2017
11. 2-(3, 4-dihydroxybenzylidene)malononitrile as a novel anti-melanogenic compound Oncotarget. 2017
12. Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway J Dermatol Sci. 2017
13. Anti-Melanogenic Activity of Gagunin D, a Highly Oxygenated Diterpenoid from the Marine Sponge Phorbas sp., via Modulating Tyrosinase Expression and Degradation Mar Drugs. 2016
14. Inhibitory effect of 2-methylnaphtho[1,2,3-de]quinolin-8-one on melanosome transport and skin pigmentation Sci Rep. 2016
15. Substance P Stimulates Endothelin 1 Secretion via Endothelin-Converting Enzyme 1 and Promotes Melanogenesis in Human Melanocytes J Invest Dermatol. 2015
16. Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12 Arch Dermatol Res. 2015
17. Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model Int J Mol Sci. 2014
18. Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis Exp Dermatol. 2013

Neoderm®-OD

No. References Journal File
1. Intratympanic administration of alpha-lipoic acid-loaded pluronic F-127 nanoparticles ameliorates acute hearing loss Nanomedicine. 2020
2. Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy Biomaterials. 2018

Neoderm®-D

No. References Journal File
1. Electric field‐induced changes in biomechanical properties in human dermal fibroblasts and a human skin equivalent Skin Res Technol. 2020
2. Effects of red ginseng on the elastic properties of human skin J Ginseng Res. 2019