Patents

No. Title App./Reg. No. App./Reg. Country
1. Method for analyzing wound healing using 3D reconstitutive skin model 10-2015-0035871 KR
2. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 10-1613618 KR
3. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom PCT/KR2015/007118 PCT
4. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 15/324,277 US
5. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 2017-501265 JP
6. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 15819565.1 EU

References : Neoderm®-ED

No. References Journal File
1. Sustained drug release behavior of captopril-incorporated chitosan/carboxymethyl cellulose biomaterials for antihypertensive therapy International Journal of Biological Macromolecules. 2024
2. Exosomes derived from human dermal fibroblasts (HDFn-Ex) alleviate DNCB-induced atopic dermatitis (AD) via PPARα Experimental Dermatology. 2023
3. Photothermally controlled drug release of naproxen-incorporated mungbean starch/PVA biomaterials adding melanin nanoparticles Process Biochemistry. 2023
4. Bioconversion of BIOGF1K, a compound-K-rich fraction from ginseng root and its effect on epidermal barrier function Heliyon. 2023
5. Topical Application of Peptide Nucleic Acid Antisense Oligonucleotide for MMP-1 and Its Potential Anti-Aging Properties Journal of Clinical Medicine. 2023
6. Safety Assessment of Starch Nanoparticles as an Emulsifier in Human Skin Cells, 3D Cultured Artificial Skin, and Human Skin Molecules. 2023
7. otential role of the cell-penetrating peptide-conjugated soluble N-ethylmaleimide-sensitive factor attachment protein receptor motif of vesicle-associated membrane protein 2-patterned peptide in novel cosmeceutical skin product development Journal of Cosmetic Dermatology. 2023
8. Exosomes derived from human dermal fibroblasts protect against UVB‑induced skin photoaging International Journal of Molecular medicine . 2023
9. Rosa gallica and its active compound, cyanidin-3,5-O-diglucoside, improve skin hydration via the GLK signaling pathway Biofactors. 2022
10. Synthesis and drug release properties of melanin added functional allopurinol incorporated starch-based biomaterials International Journal of Biological Macromolecules. 2022
11. Noninvasive Transdermal Delivery of Biomolecules Using Arc-Poration Social Science Research Network. 2022
12. Transdermal Delivery and Biological Activity of Arginine Oligomer Conjugation of Palmitoyl Tripeptide-1 International Journal of Innovative Research and Scientific Studies. 2022
13. Enhancement of Efficacy of Retinoids through Enhancing Retinoid-Induced RAR Activity and Inhibiting Hydroxylation of Retinoic Acid, and Its Clinical Efficacy on Photo-Aging Pharmaceutics. 2022
14. Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells Marine drugs. 2020
15. rhEGF Treatment Improves EGFR Inhibitor-Induced Skin Barrier and Immune Defects Cancers. 2020
16. Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model Bioorganic & Medical Chemistry Letters. 2020
17. Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis Phytomedicine. 2020
18. IL-32γ suppressed atopic dermatitis through inhibition of miR-205 expression via inactivation of nuclear factor-kappa B J allergy clin immunol. 2020
19. Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells Marine drugs. 2020
20. rhEGF Treatment Improves EGFR Inhibitor-Induced Skin Barrier and Immune Defects Cancers. 2020
21. Astragali Radix and its compound formononetin ameliorate diesel particulate matter-induced skin barrier disruption by regulation of keratinocyte proliferation and apoptosis J Ethnopharmacol. 2019
22. Sulindac imprinted mungbean starch/PVA biomaterial films as a transdermal drug delivery patch Carbohydr Polym. 2019
23. Marine Alga Ecklonia cava Extract and Dieckol Attenuate Prostaglandin E2 Production in HaCaT Keratinocytes Exposed to Airborne Particulate Matter Antioxidants (Basel). 2019
24. Astragali Radix and its compound formononetin ameliorate diesel particulate matter-induced skin barrier disruption by regulation of keratinocyte proliferation and apoptosis J Ethnopharmacol. 2019
25. Sulindac imprinted mungbean starch/PVA biomaterial films as a transdermal drug delivery patch Carbohydr Polym. 2019
26. Marine Alga Ecklonia cava Extract and Dieckol Attenuate Prostaglandin E2 Production in HaCaT Keratinocytes Exposed to Airborne Particulate Matter Antioxidants (Basel). 2019
27. PKCι is a target of 7,8,4′-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression Exp Dermatol. 2018
28. Effects on skin of Stichopus japonicus viscera extracts detected with saponin including Holothurin A: Down-regulation of melanin synthesis and upregulation of neocollagenesis mediated by ERK signaling pathway J Ethnopharmacol. 2018
29. PKCι is a target of 7,8,4′-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression Exp Dermatol. 2018
30. Effects on skin of Stichopus japonicus viscera extracts detected with saponin including Holothurin A: Down-regulation of melanin synthesis and upregulation of neocollagenesis mediated by ERK signaling pathway J Ethnopharmacol. 2018
31. The Ginsenoside Derivative 20(S)-Protopanaxadiol Inhibits Solar Ultraviolet Light-Induced Matrix Metalloproteinase-1 Expression J Cell Biochem. 2017
32. Acceleration of Apoptosis by Extracellular Basic pH in a 3D Human Skin Equivalent System Pharmacology. 2017
33. The Ginsenoside Derivative 20(S)-Protopanaxadiol Inhibits Solar Ultraviolet Light-Induced Matrix Metalloproteinase-1 Expression J Cell Biochem. 2017
34. Acceleration of Apoptosis by Extracellular Basic pH in a 3D Human Skin Equivalent System Pharmacology. 2017
35. Acceleration of Collagen Breakdown by Extracellular Basic pH in Human Dermal Fibroblasts Skin Pharmacol Physiol. 2016
36. Acceleration of Collagen Breakdown by Extracellular Basic pH in Human Dermal Fibroblasts Skin Pharmacol Physiol. 2016
37. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K PLoS One. 2015
38. Flt3 is a target of cumestrol in protecting against UVB-induced skin photoaging. Biochemical Pharmacology Biochem Pharmacol. 2015
39. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K PLoS One. 2015
40. Flt3 is a target of cumestrol in protecting against UVB-induced skin photoaging. Biochemical Pharmacology Biochem Pharmacol. 2015
41. Topical delivery of retinol mulsions co-stabilised by PEO-PCLPEO triblock copolymers: effect of PCL block length J Microencapsul. 2012
42. Topical delivery of retinol mulsions co-stabilised by PEO-PCLPEO triblock copolymers: effect of PCL block length J Microencapsul. 2012

References : Neoderm®-E

No. References Journal File
1. Screening of Plant-Derived Natural Extracts to Identify a Candidate Extract Capable of Enhancing Lipid Synthesis in Keratinocytes Annals of Dermatology. 2022
2. Antimicrobial Effect of Supercritical Robinia pseudo-acacia Leaf Extracts and Its Transdermal Delivery System with Cell Penetrating Peptide International journal of advanced culture technology. 2020
3. Adiponectin enhances human keratinocyte lipid synthesis via SIRT1 and nuclear hormone receptor signaling J Invest Dermatol. 2019
4. Evaluation of the Antiviral Activity of a Green Tea Solution as a Hand-Wash Disinfectant Biosci Biotechnol Biochem. 2012
5. Interleukin-17 and Interleukin-22 Induced Proinflammatory Cytokine Production in Keratinocytes via Inhibitor of Nuclear FactorκB Kinase-α Expression Ann Dermatol. 2012
6. Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers Exp Dermatol. 2011

References : Neoderm®-ME

No. References Journal File
1. Antimelanogenic potential of brewer's spent grain extract through modulation of the MAPK/MITF axis Sustainable Materials and Technologies. 2023
2. Neurog1-Derived Peptides RMNE1 and DualPep-Shine Penetrate the Skin and Inhibit Melanin Synthesis by Regulating MITF Transcription Journal of Functional Foods. 2023
3. Ultrasound-assisted pumpkin tendril extracts inhibits melanogenesis by suppressing the CREB/MITF signaling pathway in B16F10 melanoma cells, zebrafish, and a human skin model Journal of Functional Foods. 2023
4. Decursin prevents melanogenesis by suppressing MITF expression through the regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β cascades Biomedicine & Pharmacotherapy. 2022
5. Maclurin Exhibits Antioxidant and Anti-Tyrosinase Activities, Suppressing Melanogenesis Antioxidant. 2022
6. Neobavaisoflavone Inhibits Melanogenesis through the Regulation of Akt/GSK-3β and MEK/ERK Pathways in B16F10 Cells and a Reconstructed Human 3D Skin Model Molecules. 2020
7. Exogenous pyruvate alleviates UV-induced hyperpigmentation via restraining dendrite outgrowth and Rac1 GTPase activity J dermaltological science. 2020
8. Anti-melanogenic effects of extracellular vesicles derived from plant leaves and stems in mouse melanoma cells and human healthy skin J extracellular vesicles. 2020
9. Spinosin is a flavonoid in the seed of Ziziphus jujuba that prevents skin pigmentation in a human skin model J Funct Foods. 2019
10. Amino acids disrupt calcium-dependent adhesion of stratum corneum PLoS One. 2019
11. A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity J Dermatol Sci. 2018
12. Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio) propanoate suppresses melanogenesis through ERK signaling pathway mediated MITF proteasomal degradation J Dermatol Sci. 2018
13. Effect of 3,6‐anhydro‐l‐galactose on α‐melanocyte stimulating hormone‐induced melanogenesis in human melanocytes and a skin‐equivalent model J Cell Biochem. 2018
14. Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway J Dermatol Sci. 2017
15. 2-(3, 4-dihydroxybenzylidene)malononitrile as a novel anti-melanogenic compound Oncotarget. 2017
16. Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase Oncotarget. 2017
17. Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin Biochem Biophys Res Commun. 2017
18. Inhibitory effect of 2-methylnaphtho[1,2,3-de]quinolin-8-one on melanosome transport and skin pigmentation Sci Rep. 2016
19. Anti-Melanogenic Activity of Gagunin D, a Highly Oxygenated Diterpenoid from the Marine Sponge Phorbas sp., via Modulating Tyrosinase Expression and Degradation Mar Drugs. 2016
20. Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12 Arch Dermatol Res. 2015
21. Substance P Stimulates Endothelin 1 Secretion via Endothelin-Converting Enzyme 1 and Promotes Melanogenesis in Human Melanocytes J Invest Dermatol. 2015
22. Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model Int J Mol Sci. 2014
23. Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model Int J Mol Sci. 2014
24. Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis Exp Dermatol. 2013
25. Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis Exp Dermatol. 2013

References : Neoderm®-M

No. References Journal File
1. Anti-melanogenic effect of exosomes derived from human dermal fibroblasts (BJ-5ta-Ex) in C57BL/6 mice and B16F10 melanoma cells Pigment Cell & Melanoma Research. 2023
2. A Basic Domain-Derived Tripeptide Inhibits MITF Activity by Reducing its Binding to the Promoter of Target Genes J Invest Dermatol. 2021

References : Neoderm®-OD

No. References Journal File
1. Effect of orodispersible hyaluronic acid film on palatal mucosa wound healing Oral Diseases. 2023
2. Intratympanic administration of alpha-lipoic acid-loaded pluronic F-127 nanoparticles ameliorates acute hearing loss Nanomedicine. 2020
3. Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy Biomaterials. 2018

References : Neoderm®-D

No. References Journal File
1. Electric field‐induced changes in biomechanical properties in human dermal fibroblasts and a human skin equivalent Skin Res Technol. 2020
2. Effects of red ginseng on the elastic properties of human skin J Ginseng Res. 2019